Adam Byrne will start his first game for Leinster in almost two-years when they host Zebre in the United Rugby Championship tomorrow.
The Ireland capped winger has been sidelined with a succession of injuries since December 2019.
Jordan Larmour also returns from injury to start on the other wing at the R-D-S, with Jimmy O’Brien making his first appearance of the season at full-back.
Flanker Dan Leavy and out-half Harry Byrne have also been handed their first starts of the campaign.
Meanwhile Munster have made 11 changes for their trip to the Scarlets in the United Rugby Championship tomorrow.
Matt Gallagher, Liam Coombes and Neil Cronin all make their first appearances of the season in the Reds' backline while flanker Jack O'Donoghue skippers the side.
Ben Healy comes in to start at out-half as head-coach Johann van Graan shuffles his pack after wins against the Stormers and Sharks.
Leinster team v Zebre: Jimmy O’Brien; Adam Byrne, Jordan Larmour, Ciarán Frawley, Jamie Osborne; Harry Byrne, Luke McGrath (C); Ed Byrne, Seán Cronin, Michael Ala’alatoa; Devin Toner, Ryan Baird; Dan Leavy, Rhys Ruddock, Scott Penny.
Munster team v Scarlets: Matt Gallagher; Calvin Nash, Liam Coombes, Dan Goggin, Shane Daly; Ben Healy, Neil Cronin; Jeremy Loughman, Diarmuid Barron, Stephen Archer; Thomas Ahern, Fineen Wycherley; Jack O’Donoghue (C), Chris Cloete, Jack O’Sullivan.