A child has died from a probable case of hepatitis, the HSE has confirmed.
It's one of 6 cases of the illness identified in Ireland over the past 10 weeks.
A second child has received a liver transplant.
The children range in age from 1 to 12.
Investigations are ongoing to identify the cause of these illnesses.
According to WHO at least 169 cases of acute hepatitis in children have been reported in the UK, EU and the USA.